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KMID : 1130620080040020084
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Journal of Clinical Neurology
2008 Volume.4 No. 2 p.84 ~ p.88
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Multiplex Analysis of Cytokines in the Serum and Cerebrospinal Fluid of Patients With Alzheimer’s Disease by Color-Coded Bead Technology
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Choi Chul-Hee
Choi Kyung-Sun
Choi Kyoung-Gyu
Lee Jung-Sul
Jeong Jee-Hyang
Jang Joong-Sik
Kwon Jong-bum
Lee Jong-Seo
Kang Sang-Won
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Abstract
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Background and purpose: The availability and promise of effective treatments for neurodegenerative disorders
are increasing the importance of early diagnosis. Having molecular and biochemical markers of Alzheimer’s disease
(AD) would complement clinical approaches, and further the goals of early and accurate diagnosis. Combining
multiple biomarkers in evaluations significantly increases the sensitivity and specificity of the biochemical tests.
Methods: In this study, we used color-coded bead-based Luminex technology to test the potential of using
chemokines and cytokines as biochemical markers of AD. We measured the levels of 22 chemokines and cytokines
in the serum and cerebrospinal fluid (CSF) of 32 de novo patients (13 controls, 11 AD, and 8 Parkinson’s disease
[PD]).
Results: MCP-1 was the only cytokine detectable in CSF, and its levels did not differ between control and
disease groups. However, the serum concentration of eotaxin was significantly higher in AD patients than in the
control group.
Conclusions: The analysis of multiple inflammatory mediators revealed marginal differences in their CSF and
serum concentrations for the differential diagnosis of AD and PD. These results provide evidence that immunological
responses are not major contributors to the pathogenesis of AD and PD.
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KEYWORD
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Alzheimer’s disease, Biomarker, Serum, Cerebrospinal fluid, Neurodegeneration
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